Researchers map paths to cancer drug resistance

A team of researchers have identified key events that prompt certain cancer cells to develop resistance to otherwise lethal therapies.By mapping the specific steps that cells of melanoma, breast cancer and a blood cancer called myelofibrosis use to become resistant to drugs, the researchers now have much better targets for blocking those pathways and keeping … Continue reading Researchers map paths to cancer drug resistance

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Breast reconstruction using patient’s own tissues yield higher satisfaction rates

New insights for patient decision-making, suggests study in plastic and reconstructive surgery For women who have undergone mastectomy, breast reconstruction using the patient's own tissues, rather than implants, provides higher satisfaction scores, reports a study in Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons (ASPS). But the findings may at … Continue reading Breast reconstruction using patient’s own tissues yield higher satisfaction rates

Risk for leukemia after treatment for early-stage breast cancer higher than reported

The risk of developing leukemia after radiation therapy or chemotherapy for early stage breast cancer remains very small, but it is twice as high as previously reported, according to results of a new study led by researchers at the Johns Hopkins Kimmel Cancer Center. The study team reviewed data on 20,063 breast cancer patients treated … Continue reading Risk for leukemia after treatment for early-stage breast cancer higher than reported

Youngest bone marrow transplant patients at higher risk of cognitive decline

St. Jude Children's Research Hospital study identifies small group of patients at risk for intellectual decline after bone marrow transplantation; results set stage for new strategies to preserve IQ and fight cancer. Toddlers who undergo total body irradiation in preparation for bone marrow transplantation are at higher risk for a decline in IQ and may … Continue reading Youngest bone marrow transplant patients at higher risk of cognitive decline

New drug combination for advanced breast cancer delays disease progression

A new combination of cancer drugs delayed disease progression for patients with hormone-receptor-positive metastatic breast cancer, according to a multi-center phase II trial.  The findings of the randomized study were presented at the 2014 San Antonio Breast Cancer Symposium, by Kerin Adelson, M.D., assistant professor of medical oncology at Yale Cancer Center and chief quality … Continue reading New drug combination for advanced breast cancer delays disease progression

HIV drug blocks bone metastases in prostate cancer

The receptor CCR5, targeted by HIV drugs, is also key in driving prostate cancer metastases, suggesting that blocking this molecule could slow prostate cancer spread. Although prostate cancer can be successfully treated in many men, when the disease metastasizes to the bone, it is eventually lethal. In a study published online in the journal Cancer Research, researchers … Continue reading HIV drug blocks bone metastases in prostate cancer

Survival differences seen for advanced-stage laryngeal cancer

The five-year survival rate for advanced-stage laryngeal cancer was higher than national levels in a small study at a single academic center performing a high rate of surgical therapy, including a total laryngectomy (removal of the voice box), to treat the disease, despite a national trend toward organ preservation, according to a report published online … Continue reading Survival differences seen for advanced-stage laryngeal cancer