Early deaths from childhood cancer up to 4 times more common than previously reported

Treatments for childhood cancers have improved to the point that 5-year survival rates are over 80 percent. However, one group has failed to benefit from these improvements, namely children who die so soon after diagnosis that they are not able to receive treatment, or who receive treatment so late in the course of their disease … Continue reading Early deaths from childhood cancer up to 4 times more common than previously reported

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Treatment significantly reduces chemotherapy-induced hearing loss in children

Investigators from Children's Hospital Los Angeles and 37 other Children's Oncology Group hospitals in the U.S. and Canada have determined that sodium thiosulfate prevents cisplatin-induced hearing loss in children and adolescents with cancer. Results of this randomized, controlled, phase 3 study, called ACCL0431, have been published in the early online edition of Lancet Oncology. "This federally-funded, … Continue reading Treatment significantly reduces chemotherapy-induced hearing loss in children

Eye movement affected in former childhood cancer patients

Nowadays, the lives of the majority of all children with cancer can be spared. However, the cure for the disease comes with a price: some of the survivors will suffer long-term injury from the treatment. A study from Lund University in Sweden now shows that commonly used chemo toxins impair the eyesight in childhood cancer … Continue reading Eye movement affected in former childhood cancer patients

Bone loss associated with leukemia therapy occurs sooner than previously thought

Investigators at Children's Hospital Los Angeles have found that significant bone loss - a side effect of chemotherapy for acute lymphoblastic leukemia (ALL) - occurs during the first month of treatment, far earlier than previously assumed. Results of the study will be available online in advance of publication in the journal Bone. ALL is the most … Continue reading Bone loss associated with leukemia therapy occurs sooner than previously thought

Two studies examine long-term outcomes in childhood and young adult cancer survivors

JAMA Oncology published two studies and a related editorial focused on long-term outcomes in survivors of childhood or young adult cancer. In the first study, Kathrine Rugbjerg, PhD, and Jørgen Olsen, MD, DMSc, of the Danish Cancer Society Research Center, Copenhagen, examined the risk for hospitalization up to 34 years after a diagnosis of adolescent and … Continue reading Two studies examine long-term outcomes in childhood and young adult cancer survivors

Youngest bone marrow transplant patients at higher risk of cognitive decline

St. Jude Children's Research Hospital study identifies small group of patients at risk for intellectual decline after bone marrow transplantation; results set stage for new strategies to preserve IQ and fight cancer. Toddlers who undergo total body irradiation in preparation for bone marrow transplantation are at higher risk for a decline in IQ and may … Continue reading Youngest bone marrow transplant patients at higher risk of cognitive decline

Updating cardiac screening guidelines for survivors of childhood cancer

Findings suggest that there is a long-term benefit in screening survivors at elevated risk for congestive heart failure.  One of the first studies to analyze the effectiveness of screening survivors of childhood cancer for early signs of impending congestive heart failure (CHF) finds improved health outcomes but suggests that less frequent screening than currently recommended may … Continue reading Updating cardiac screening guidelines for survivors of childhood cancer

Early detection of childhood eye cancer doesn’t always improve survival or prevent eye loss

For the most common form of childhood eye cancer, unilateral retinoblastoma, shortening the time from the first appearance of symptoms to diagnosis of disease has no bearing on survival or stage of the disease, according to a study by researchers at Columbia University Mailman School of Public Health in partnership with the Hospital Infantil de … Continue reading Early detection of childhood eye cancer doesn’t always improve survival or prevent eye loss

Health gap between adult survivors of childhood cancer and siblings widens with age

Long-term follow-up of adult survivors of childhood cancer reinforces need for lifelong health surveillance for childhood cancer survivorsAdult survivors of childhood cancer face significant health problems as they age and are five times more likely than their siblings to develop new cancers, heart and other serious health conditions beyond the age of 35, according to … Continue reading Health gap between adult survivors of childhood cancer and siblings widens with age

Study finds strong pregnancy outcomes for survivors of childhood cancer

Although women who survived childhood cancer face an increased risk of infertility, nearly two-thirds of those who tried unsuccessfully to become pregnant for at least a year eventually conceived, according to clinical researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Brigham and Women's Hospital. This is comparable to the rate of eventual pregnancy … Continue reading Study finds strong pregnancy outcomes for survivors of childhood cancer